This is from a study in Germany…
“The protein p27 is a nuclear cell cycle inhibitor that can be shuttled to the cytoplasm to inactivate its inhibitory role, and this mechanism is thought to be used by cancer cells to unlock cell cycle arrest. Recent reports, however, have shown that p27 has other roles independent of cell cycle regulation, and it was observed that p27 mutant mice had increased mortality to myocardial infarction. Here, we have analyzed the potential role of p27 in the major cell types of the heart and shown that it is also present in mitochondria, the cellular powerhouses, where it fulfills important functions. We find that p27 is required for migration of endothelial cells by enhancing mitochondrial functions and that caffeine concentrations reached after consumption of 4 cups of coffee induce its translocation into mitochondria. Moreover, we observe that mitochondrial p27 protects heart muscle cells from cell death and is necessary for the conversion of fibroblasts into mechanically strong, contractile myofibroblasts, a process critical after myocardial infarction. Molecularly, we show that p27 is essential for caffeine-induced gene expression changes that mainly affect mitochondria and for mitochondrial respiration. We conclude that mitochondrial p27 improves mitochondria-dependent processes in heart cells and that physiological concentrations of caffeine have a protective effect.”
Not only does it have all of the cognitive benefits, but it helps your mitochondria as well and from this study, the researchers also believe it can protect your heart and help you live longer!
Here is the whole study that you can read yourself.
http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2004408
